Maternal growth factor regulation of human placental development and fetal growth
نویسندگان
چکیده
منابع مشابه
Maternal growth factor regulation of human placental development and fetal growth.
Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development a...
متن کاملPlacental Growth, Fetal Growth and Maternal RhE Genotype
The Rh locus is composed of two genes RhD, which encodes the major D antigen and is present only in Rh-positive genomes, and RhCE, which encodes both the Cc and Ee polypeptides, most likely by alternative splicing events. Several membrane components, including Rh proteins and other glycoproteins recently characterized, are probably different subunits of an oligomeric complex with transport func...
متن کاملPlacental regulation of maternal-fetal interactions and brain development.
A variety prenatal insults are associated with the incidence of neurodevelopmental disorders such as schizophrenia, autism and cerebral palsy. While the precise mechanisms underlying how transient gestational challenges can lead to later life dysfunctions are largely unknown, the placenta is likely to play a key role. The literal interface between maternal and fetal cells resides in the placent...
متن کاملHuman placental growth hormone in normal and abnormal fetal growth
Human placental growth hormone (PGH), encoded by the growth hormone (GH) variant gene on chromosome 17, is expressed in the syncytiotrophoblast and extravillous cytotrophoblast layers of the human placenta. Its maternal serum levels increase throughout pregnancy, and gradually replaces the pulsatile secreted pituitary GH. PGH is also detectable in cord blood and in the amniotic fluid. This plac...
متن کاملPlacental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation.
BACKGROUND The pathogenetic mechanisms of fetal growth restriction associated with placental malaria are largely unknown. We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth. METHOD We measured IGF-1 and IGF-2 concentrations in plasma from 88 mother-neonate p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2010
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe-10-0174